Large-scale brain systems in ADHD: beyond the prefrontal-striatal model – F. Xavier Castellanos and Erika Proal

Recent advances in systems neuroscience-based approaches to brain dysfunction have facilitated the development of models of ADHD pathophysiology that encompass a number of different large-scale resting-state networks.

Article Abstract

Attention-deficit/hyperactivity disorder (ADHD) has long been thought to reflect dysfunction of prefrontal-striatal circuitry, with involvement of other circuits largely ignored. Recent advances in systems neuroscience-based approaches to brain dysfunction have facilitated the development of models of ADHD pathophysiology that encompass a number of different large-scale resting-state networks. Here we review progress in delineating large-scale neural systems and illustrate their relevance to ADHD. We relate frontoparietal, dorsal attentional, motor, visual and default networks to the ADHD functional and structural literature. Insights emerging from mapping intrinsic brain connectivity networks provide a potentially mechanistic framework for an understanding of aspects of ADHD such as neuropsychological and behavioral inconsistency, and the possible role of primary visual cortex in attentional dysfunction in the disorder.

MARIO Connections

Castellanos and Proal’s study has influenced MARIO’s envisioning of the teacher-student relationship in that an educator with a solid understanding of neuropsychological functioning can better optimize the interventions utilized with learners. This study also presents a pathway for exploring how neuroplasticity can be considered when planning for productive conversations with MARIO learners.

You May Also Like
This study suggested that inclusion requires more collaborative learning environments and student-c...
This work further investigates key topics such as the defining properties of the bio-ecological mod...
In November 2008, John Hattie’s ground-breaking book Visible Learning synthesized the results of ...
Comprehensive Solutions

Take professional learning further. Our world-class courses teach educators and assistants how to leverage the MARIO Approach and build a MARIO classroom. Our software empowers learners and makes MTSS implementation easier and more effective.

Learn more
Rectangle-74-1
mario-wp-founder-philip-with-text-join-the-family-subscriber

Join the MARIO Family

We are a dedicated group of learners that are constantly seeking to improve the lives of the children we care for. Whether you are a teacher, parent, assistant, or administrator, we give you free access to the most recent special education related research and practices available. Our twice monthly MARIO Memo summarizes and shares studies from peer-reviewed journals, while our learning letters provide insights from MARIO classrooms.

Subscribe

Please enter the correct email

Join the MARIO Family

We are a dedicated group of learners that are constantly seeking to improve the lives of the children we care for. Whether you are a teacher, parent, assistant, or administrator, we give you free access to the most recent special education related research and practices available. Our twice monthly MARIO Memo summarizes and shares studies from peer-reviewed journals, while our learning letters provide insights from MARIO classrooms.

Subscribe

Please enter the correct email

mario-wp-founder-philip-with-text-join-the-family-subscriber